Tumor derived exosome induction of the CD3+CD8+ T cell tolerogenic phenotype
نویسندگان
چکیده
Background Traditionally, CD8+ T cells have been defined as being immunogenic; however, they have also been shown to demonstrate a tolerogenic phenotype. One area less studied, regarding the tolerogenic phenotype of CD8+ T cells, is their role in cancer. What has been described is that their suppressive phenotype is suggested to be developed in the tumor microenvironment and can be correlated with the CD8+ T cells becoming CD27/28-. What is unclear is the general mechanism that may trigger the tolerogenic development in CD8+ T cells. Via multiple cancer cell lines, this research identified that tumor derived (TD) exosomes will cause the development of the tolerogenic phenotype in CD3+CD8+ T cells.
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